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KMID : 1143220190620040233
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Obstetrics & Gynecology Science
2019 Volume.62 No. 4 p.233 ~ p.241
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Is preeclampsia itself a risk factor for the development of metabolic syndrome after delivery?
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Cho Geum-Joon
Jung Un-Suk
Sim Jae-Young
Lee Yoo-Jin
Bae Na-Young
Choi Hye-Jin
Park Jong-Heon
Kim Hai-Joong
Oh Min-Jeong
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Abstract
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Objective: This study aimed to determine the association between preeclampsia and the postpartum development of metabolic syndrome based on the pre-pregnancy status.
Methods: Korean women who delivered their first child between January 1, 2011, and December 31, 2012, were enrolled. All subjects underwent a national health screening examination conducted by the National Health Insurance Corporation 1 or 2 years prior to their first delivery and within 2 years after their first delivery.
Results: Among the 49,065 participants, preeclampsia developed in 3,391 participants (6.9%). The prevalence of metabolic syndrome was higher postpartum in women with preeclampsia than in those without preeclampsia (4.9% vs. 2.7%, respectively, P<0.001). Through the pre-pregnancy to postpartum period, women with preeclampsia had a greater increase in gestational weight retention, body mass index, waist circumference, systolic blood pressure, and triglyceride levels and a greater decrease in high-density lipoprotein cholesterol levels than women without preeclampsia. Preeclampsia was associated with an increased risk of the postpartum development of metabolic syndrome in women without pre-pregnancy metabolic syndrome (odds ratio, 1.28; 95% confidence interval, 1.05?1.56). However, preeclampsia was not associated with postpartum metabolic syndrome in women with pre-pregnancy metabolic syndrome or 2 components of metabolic syndrome.
Conclusion: In this study, preeclampsia was associated with the postpartum development of metabolic syndrome in women without pre-pregnancy metabolic syndrome. However, the effects were attenuated by predisposing risk factors in the pre-pregnancy period.
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KEYWORD
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Preeclampsia, Metabolic syndrome, Cardiovascular disease, Diabetes mellitus, Hypertension
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